Quenched lattice calculation of the B --> D l nu decay rate

We calculate, in the continuum limit of quenched lattice QCD, the form factor that enters in the decay rate of the semileptonic decay B --> D l nu. Making use of the step scaling method (SSM), previously introduced to handle two scale problems in lattice QCD, and of flavour twisted boundary conditions we extract G(w) at finite momentum transfer and at the physical values of the heavy quark masses. Our results can be used in order to extract the CKM matrix element Vcb by the experimental decay rate without model dependent extrapolations.Comment: 5 pages, 4 figures, accepted for publication on Phys. Lett. B, corrected one typ

A low complexity resource allocation algorithm for multicast service delivery in OFDMA networks

Allocating and managing radio resources to multicast transmissions in Orthogonal Frequency-Division Multiple Access (OFDMA) systems is the challenging research issue addressed by this paper. A subgrouping technique, which divides the subscribers into subgroups according to the experienced channel quality, is considered to overcome the throughput limitations of conventional multicast data delivery schemes. A low complexity algorithm, designed to work with different resource allocation strategies, is also proposed to reduce the computational complexity of the subgroup formation problem. Simulation results, carried out by considering the Long Term Evolution (LTE) system based on OFDMA, testify the effectiveness of the proposed solution, which achieves a near-optimal performance with a limited computational load for the system

Colour and stellar population gradients in galaxies

We discuss the colour, age and metallicity gradients in a wide sample of local SDSS early- and late-type galaxies. From the fitting of stellar population models we find that metallicity is the main driver of colour gradients and the age in the central regions is a dominant parameter which rules the scatter in both metallicity and age gradients. We find a consistency with independent observations and a set of simulations. From the comparison with simulations and theoretical considerations we are able to depict a general picture of a formation scenario.Comment: 4 pages, 4 figures. Proceedings of 54th Congresso Nazionale della SAIt, Napoli 4-7 May 201

Indirect Signatures of Type I See-Saw Scenarios

We consider the low energy constraints that can be applied to type I see-saw extensions of the Standard Model in which the right-handed neutrinos are taken at the electroweak scale. In the reported scenarios, the flavour structure of the charged current and neutral current weak interactions of the Standard Model leptons with the heavy right-handed neutrinos is essentially determined by the neutrino oscillation parameters. In this case, correlations among different measurable phenomena in the lepton sector may provide compelling indirect evidence of low energy see-saw mechanism of neutrino mass generation.Comment: 4 pages, 2 figures. Contributions to the Proceedings of the 12th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011), Munich, Germany, 5-9 September 201

Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor.

BackgroundAlthough the contrast-enhancing (CE) lesion on T1-weighted MR images is widely used as a surrogate for glioblastoma (GBM), there are also non-enhancing regions of infiltrative tumor within the T2-weighted lesion, which elude radiologic detection. Because non-enhancing GBM (Enh-) challenges clinical patient management as latent disease, this study sought to characterize ex vivo metabolic profiles from Enh- and CE GBM (Enh+) samples, alongside histological and in vivo MR parameters, to assist in defining criteria for estimating total tumor burden.MethodsFifty-six patients with newly diagnosed GBM received a multi-parametric pre-surgical MR examination. Targets for obtaining image-guided tissue samples were defined based on in vivo parameters that were suspicious for tumor. The actual location from where tissue samples were obtained was recorded, and half of each sample was analyzed for histopathology while the other half was scanned using HR-MAS spectroscopy.ResultsThe Enh+ and Enh- tumor samples demonstrated comparable mitotic activity, but also significant heterogeneity in microvascular morphology. Ex vivo spectroscopic parameters indicated similar levels of total choline and N-acetylaspartate between these contrast-based radiographic subtypes of GBM, and characteristic differences in the levels of myo-inositol, creatine/phosphocreatine, and phosphoethanolamine. Analysis of in vivo parameters at the sample locations were consistent with histological and ex vivo metabolic data.ConclusionsThe similarity between ex vivo levels of choline and NAA, and between in vivo levels of choline, NAA and nADC in Enh+ and Enh- tumor, indicate that these parameters can be used in defining non-invasive metrics of total tumor burden for patients with GBM

Online Independent Set Beyond the Worst-Case: Secretaries, Prophets, and Periods

We investigate online algorithms for maximum (weight) independent set on graph classes with bounded inductive independence number like, e.g., interval and disk graphs with applications to, e.g., task scheduling and spectrum allocation. In the online setting, it is assumed that nodes of an unknown graph arrive one by one over time. An online algorithm has to decide whether an arriving node should be included into the independent set. Unfortunately, this natural and practically relevant online problem cannot be studied in a meaningful way within a classical competitive analysis as the competitive ratio on worst-case input sequences is lower bounded by $\Omega(n)$. As a worst-case analysis is pointless, we study online independent set in a stochastic analysis. Instead of focussing on a particular stochastic input model, we present a generic sampling approach that enables us to devise online algorithms achieving performance guarantees for a variety of input models. In particular, our analysis covers stochastic input models like the secretary model, in which an adversarial graph is presented in random order, and the prophet-inequality model, in which a randomly generated graph is presented in adversarial order. Our sampling approach bridges thus between stochastic input models of quite different nature. In addition, we show that our approach can be applied to a practically motivated admission control setting. Our sampling approach yields an online algorithm for maximum independent set with competitive ratio $O(\rho^2)$ with respect to all of the mentioned stochastic input models. for graph classes with inductive independence number $\rho$. The approach can be extended towards maximum-weight independent set by losing only a factor of $O(\log n)$ in the competitive ratio with $n$ denoting the (expected) number of nodes

Cross-Validating and Bagging Partitioning Algorithms with Variable Importance

We present a cross-validated bagging scheme in the context of partitioning algorithms. To explore the benefits of the various bagging scheme, we compare via simulations the predictive ability of single Classification and Regression (CART) Tree with several previously suggested bagging schemes and with our proposed approach. Additionally, a variable importance measure is explained and illustrated

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival.

BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type. Nomograms are useful tools for individualized estimation of survival. This study aimed to develop and independently validate a nomogram for IDH-wild-type patients with newly diagnosed GBM.MethodsData were obtained from newly diagnosed GBM patients from the Ohio Brain Tumor Study (OBTS) and the University of California San Francisco (UCSF) for diagnosis years 2007-2017 with the following variables: age at diagnosis, sex, extent of resection, concurrent radiation/temozolomide (TMZ) status, Karnofsky Performance Status (KPS), O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and IDH mutation status. Survival was assessed using Cox proportional hazards regression, random survival forests, and recursive partitioning analysis, with adjustment for known prognostic factors. The models were developed using the OBTS data and independently validated using the UCSF data. Models were internally validated using 10-fold cross-validation and externally validated by plotting calibration curves.ResultsA final nomogram was validated for IDH-wild-type newly diagnosed GBM. Factors that increased the probability of survival included younger age at diagnosis, female sex, having gross total resection, having concurrent radiation/TMZ, having a high KPS, and having MGMT methylation.ConclusionsA nomogram that calculates individualized survival probabilities for IDH-wild-type patients with newly diagnosed GBM could be useful to physicians for counseling patients regarding treatment decisions and optimizing therapeutic approaches. Free software for implementing this nomogram is provided: https://gcioffi.shinyapps.io/Nomogram_For_IDH_Wildtype_GBM_H_Gittleman/